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Neurodevelopmental Consequences of Perinatal Brain Injuries
Highlights from 13th Hershey Conference on Developmental Brain Injury.
This collection includes articles presented at the 13th Hershey Conference on Developmental Brain Injury (Union, WA, USA, May 31-June 3, 2022), organized by Drs. Juul, Wood, Nance, Vannucci, Ferriero, Hagberg, Gressens, Chavez-Valdez, Sebir, and Levison, and financially supported by NIH (NINDS 1R13NS127525), Cerebral Palsy Alliance Research Foundation, Burroughs Wellcome Fund, and Karger Publishing House. The conference brought together clinicians and basic scientists with the goal of understanding the mechanisms that lead to perinatal brain injury, with specific emphasis on inflammation, epigenetics, brain development, and potential treatment strategies.
The articles collated here focus on:
- diverse mechanisms that contribute to developmental brain injuries including immune activation, microbiome, social determinants, and health disparities;
- MRI and blood-based biomarkers for assessing and predicting brain injury as well as progress in testing new neuroprotective therapies or refining existing paradigms;
- short and long-term consequences of premature birth and perinatal hypoxia-ischemia.
This special issue is relevant to both clinicians and basic scientists interested in the developing nervous system, its vulnerability to injury, and the progress in preventing short and long-term consequences of antenatal and term insults on brain health and function.
Edited by
Raul Chavez-Valdez, MD,PhD – Johns Hopkins University, School of Medicine, Baltimore, MD
Jessica L. Wisnowski, PhD – Children’s Hospital Los Angeles, Keck School of Medicine of USC., Los Angeles, CA
Steven W. Levison, PhD – Rutgers Biomedial Health Sciences-New Jersey Medical School, Newark, NJ
Check Out Our Special Selection Articles
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Preterm Birth by Cesarean Section: The Gut-Brain Axis, a Key Regulator of Brain Development
Cécile Morin; Cindy Bokobza; Bobbi Fleiss; Elisa L. Hill-Yardin; Juliette Van Steenwinckel; Pierre Gressens
Dev Neurosci 1–9. (DOI:10.1159/000534124) -
Quantification of Diffusion Magnetic Resonance Imaging for Prognostic Prediction of Neonatal Hypoxic-Ischemic Encephalopathy
Kengo Onda; Raul Chavez-Valdez; Ernest M. Graham; Allen D. Everett; Frances J. Northington; Kenichi Oishi
Dev Neurosci 1–14. (DOI:10.1159/000530938) -
Brain Injury Outcomes after Adjuvant Erythropoietin Neuroprotection for Moderate or Severe Neonatal Hypoxic-Ischemic Encephalopathy: A Report from the HEAL Trial
Jessica L. Wisnowski; Sarah E. Monsell; Stefan Bluml; Amy M. Goodman; Yi Li; Bryan A. Comstock; Patrick J. Heagerty; Sandra E. Juul; Yvonne W. Wu; Robert C. McKinstry; Amit M. Mathur; On behalf of the HEAL Consortium
Dev Neurosci 1–12. (DOI:10.1159/000534618) -
Does Perinatal Intermittent Hypoxia Affect Cerebrovascular Network Development?
Vanessa Coelho-Santos; Anne-Jolene N. Cruz; Andy Y. Shih
Dev Neurosci 1–11. (DOI:10.1159/000530957) -
Fetal Origins of Health Disparities: Transgenerational Consequences of Racism
Nana Matoba; James W. Collins; Maria L.V. Dizon
Dev Neurosci 1–7. (DOI:10.1159/000531462) -
Neuroprotective Effects of Delayed TGF-β1 Receptor Antagonist Administration on Perinatal Hypoxic-Ischemic Brain Injury
Hur Dolunay Kanal; Steven W. Levison
Dev Neurosci 1–13. (DOI:10.1159/000531650) -
Hypothermia Treatment after Hypoxia-Ischemia in Glutathione Peroxidase-1 Overexpressing Mice
R. Ann Sheldon; Christine Windsor; Fuxin Lu; Nicholas R. Stewart; Xiangning Jiang; Donna M. Ferriero
Dev Neurosci 1–14. (DOI:10.1159/000531204) -
Sexual Dimorphism in the Closure of the Hippocampal Postnatal Critical Period of Synaptic Plasticity after Intrauterine Growth Restriction: Link to Oligodendrocyte and Glial Dysregulation
Michael Nugent; Mark St. Pierre; Ashley Brown; Salma Nassar; Pritika Parmar; Yuma Kitase; Sarah Ann Duck; Charles Pinto; Lauren Jantzie; Camille Fung; Raul Chavez-Valdez
Dev Neurosci (2023) 45 (5): 234–254. (DOI:10.1159/000530451) -
Developmental brain injury and social determinants of health: opportunities to combine preclinical models for mechanistic insights into recovery
Danielle Guez-Barber; Amelia Eisch; Ana G. Cristancho
Dev Neurosci (2023) 45 (5): 255–267. (DOI:10.1159/000530745) -
Blood biomarkers in the fetally growth restricted and small for gestational age neonate: associations with brain injury
Hannah Musco; Kate Beecher; Kirat K. Chand; Paul B. Colditz; Julie A. Wixey
Dev Neurosci 1. (DOI:10.1159/000530492) -
Dendrimer-Conjugated Glutamate Carboxypeptidase II Inhibitor Restores Microglial Changes in a Rabbit Model of Cerebral Palsy
Nirnath Sah; Zhi Zhang; Alicia Chime; Amanda Fowler; Antonio Mendez-Trendler; Anjali Sharma; Rangaramanujam M. Kannan; Barbara Slusher; Sujatha Kannan
Dev Neurosci (2023) 45 (5): 268–275. (DOI:10.1159/000530389) -
The Outcomes of Maternal Immune Activation Induced with the Viral Mimetic Poly I:C on Microglia in Exposed Rodent Offspring
Sophia M. Loewen; Adriano M. Chavesa; Colin J. Murray; Marianela E. Traetta; Sophia E. Burns; Keelin H. Pekarik; Marie-Ève Tremblay
Dev Neurosci (2023) 45 (4): 191–209. (DOI:10.1159/000530185)
Check Out Highlighted Articles from Previous Hershey Conferences
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Sex-Dependent Gliovascular Interface Abnormality in the Hippocampus following Postnatal Immune Activation in Mice
Maryam Ardalan; Tetyana Chumak; Alexandra Quist; Seyedeh Marziyeh Jabbari Shiadeh; Anna-Jean Mallard; Ali Hoseinpoor Rafati; Carina Mallard
Dev Neurosci (2022) 44 (4-5): 320–330. (DOI:10.1159/000525478) -
Infantile Cocktail of Erythropoietin and Melatonin Restores Gait in Adult Rats with Preterm Brain Injury
Lauren L. Jantzie; Sankar Muthukumar; Yuma Kitase; Vikram Vasan; Mohammed A. Fouda; Sarah Hamimi; Christopher Burkhardt; Vera Joanna Burton; Gwendolyn Gerner; Joseph Scafidi; Xiaobu Ye; Frances J. Northington; Shenandoah Robinson
Dev Neurosci (2022) 44 (4-5): 266–276. (DOI:10.1159/000524394) -
Golgipathies in Neurodevelopment: A New View of Old Defects
Sowmyalakshmi Rasika; Sandrine Passemard; Alain Verloes; Pierre Gressens; Vincent El Ghouzzi
Dev Neurosci (2019) 40 (5-6): 396–416. (DOI:10.1159/000497035) -
Optimizing Cerebral Autoregulation May Decrease Neonatal Regional Hypoxic-Ischemic Brain Injury
Jennifer K. Lee; Andrea Poretti; Jamie Perin; Thierry A.G.M. Huisman; Charlamaine Parkinson; Raul Chavez-Valdez; Matthew O'Connor; Michael Reyes; Jillian Armstrong; Jacky M. Jennings; Maureen M. Gilmore; Raymond C. Koehler; Frances J. Northington; Aylin Tekes
Dev Neurosci (2017) 39 (1-4): 248–256. (DOI:10.1159/000452833) -
A Critical Review of Models of Perinatal Infection
Justin M. Dean; Zhongjie Shi; Bobbi Fleiss; Katherine C. Gunn; Floris Groenendaal; Frank van Bel; Matthew Derrick; Sandra E. Juul; Sidhartha Tan; Pierre Gressens; Carina Mallard; Laura Bennet; Alistair J. Gunn
Dev Neurosci (2015) 37 (4-5): 289–304. (DOI:10.1159/000370309) -
Human Umbilical Cord Blood Cells Ameliorate Motor Deficits in Rabbits in a Cerebral Palsy Model
Alexander Drobyshevsky; C. Michael Cotten; Zhongjie Shi; Kehuan Luo; Rugang Jiang; Matthew Derrick; Elizabeth T. Tracy; Tracy Gentry; Ronald N. Goldberg; Joanne Kurtzberg; Sidhartha Tan
Dev Neurosci (2015) 37 (4-5): 349–362. (DOI:10.1159/000374107) -
Concurrent Erythropoietin and Hypothermia Treatment Improve Outcomes in a Term Nonhuman Primate Model of Perinatal Asphyxia
Christopher M. Traudt; Ronald J. McPherson; Larry A. Bauer; Todd L. Richards; Thomas M. Burbacher; Ryan M. McAdams; Sandra E. Juul
Dev Neurosci (2013) 35 (6): 491–503. (DOI:10.1159/000355460) -
Strain-Specific Differences in Perinatal Rodent Oligodendrocyte Lineage Progression and Its Correlation with Human
Justin M. Dean; Matthew D. Moravec; Marjorie Grafe; Nicholas Abend; Jennifer Ren; Xi Gong; Joseph J. Volpe; Frances E. Jensen; A. Roger Hohimer; Stephen A. Back
Dev Neurosci (2011) 33 (3-4): 251–260. (DOI:10.1159/000327242) -
Does Inflammation after Stroke Affect the Developing Brain Differently than Adult Brain?
Zinaida S. Vexler; Midori A. Yenari
Dev Neurosci (2009) 31 (5): 378–393. (DOI:10.1159/000232556) -
Erythropoietin Enhances Long-Term Neuroprotection and Neurogenesis in Neonatal Stroke
Fernando F. Gonzalez; Patrick McQuillen; Dezhi Mu; Yunsil Chang; Michael Wendland; Zinaida Vexler; Donna M. Ferriero
Dev Neurosci (2007) 29 (4-5): 321–330. (DOI:10.1159/000105473) -
Perinatal Hypoxic-Ischemic Brain Damage: Evolution of an Animal Model
Robert C. Vannucci; Susan J. Vannucci
Dev Neurosci (2005) 27 (2-4): 81–86. (DOI:10.1159/00085978) -
Melatonin Provides Neuroprotection in the Late-Gestation Fetal Sheep Brain in Response to Umbilical Cord Occlusion
MSuzanne L. Miller; Edwin B. Yan; Margie Castillo-Meléndez; Graham Jenkin; David W. Walker
Dev Neurosci (2005) 27 (2-4): 200–210. (DOI:10.1159/00085993)
Special Issues Born from the Hershey Conferences Published in Developmental Neuroscience
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Vol. 44, No. 4–5, 2022
Challenges and Opportunities in Developmental Brain Injuries
12th Hershey Conference on Developmental Brain Injury, Virtual Meeting held on Pheedloop, June 3–4, 2021
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Vol. 40, No. 5–6, 2018
Mechanisms of Developmental Brain Injuries
11th Hershey Conference on Developmental Brain Injury, Asilomar, CA, June 2018
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Vol. 39, No. 1–4, 2017
Cutting-Edge Concepts in Perinatal Brain Damage
10th Hershey Conference on Developmental Brain Injury, Ecquevilly, June 2016
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Vol. 37, No. 4–5, 2015
Cell Death and Plasticity in Developmental Brain Injury
9th Hershey Conference on Developmental Brain Injury, St. Michaels, Md., June 2014
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Vol. 35, No. 2–3, 2013
Inflammation and the Developing Brain
8th Hershey Conference on Developmental Brain Injury, London, June 2012
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Vol. 33, No. 3–4, 2011
Frontiers in Perinatal Neuroprotection
7th Hershey Conference on Developmental Brain Injury, Snowbird, Utah, June 2010
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Vol. 31, No. 5, 2009
Progress in Fetal and Neonatal Brain Injury Research
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Vol. 29, No. 4–5, 2007
Bridging Bench to Bedside in Fetal and Neonatal Brain Injury
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Vol. 27, No. 2–4, 2005
Developmental Brain Injury
4th Hershey Conference, Pacific Grove, Calif., June 2004: Proceedings and Abstracts
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Vol. 24, No. 5, 2002
Developmental Brain Injury
3rd Hershey Conference on Developmental Cerebral Blood Flow and Metabolism, Hershey, Pa., June 2002: Proceedings and Abstracts
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Vol. 23, No. 3, 2001
Perinatal Brain Injury
2nd Hershey Conference on Developmental Cerebral Blood Flow and Metabolism, Hershey, Pa., June 2000: Proceedings and Abstracts
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